Akupunkturtherapie bei Post-Stroke-Spastik: eine systematische Übersichtsarbeit und explorative Netzwerk-Metaanalyse zu klinischer Wirksamkeit und Dosis-Wirkungs-Beziehung Abstract Background and purpose Acupuncture has shown good therapeutic potential in post-stroke spasticity (PSS). We aimed to evaluate the clinical efficacy and optimal acupuncture type and dose of acupuncture for PSS. Methods A comprehensive literature search was conducted across 8 databases (PubMed, Embase, Web of Science, Cochrane Library, Chinese National Knowledge Infrastructure (CNKI), Chinese Science and Technology Periodical Databases (VIP), Chinese Biomedical Literature database (Sinomed), and Wan Fang database) to search randomized controlled trials (RCTs) of acupuncture for PSS from their inception to December 1, 2025....Weiterlesen

Neuroplastische Mechanismen der Akupunktur bei der motorischen Erholung nach Schlaganfall: Eine randomisierte Multimodal-MRT-Studie Abstract Background Hemiplegia is a common motor impairment following ischemic stroke. Post-stroke recovery involves extensive reorganization of structural and functional brain networks, which correlates with clinical deficits and recovery. While acupuncture has demonstrated safety and efficacy in improving motor function, robust neuroimaging evidence elucidating its central mechanisms remains limited. This study aimed to investigate the specific neuroplastic effects of acupuncture by focusing on its modulation of cortical gray matter volume (GMV) and multilayer dynamic functional network topology. Methods Patients with stroke were randomly allocated in a 2:1...Weiterlesen

Aktueller Stand und zukünftige Perspektiven der Akupunktur bei Insomnie: Von zentralen Mechanismen zu peripheren Effekten Abstract Insomnia significantly impacts mental health and is linked to a range of other health issues, including cardiovascular diseases, depression and anxiety. Acupuncture, a traditional non-pharmacological intervention, enhances sleep quality by modulating neural circuits and neurotransmitter systems within the brain, particularly in regions such as the hypothalamus, brainstem, and limbic system. It can regulate circadian rhythms, facilitate the equilibrium of neurohormones and neurotransmitters, including melatonin, 5-hydroxytryptamine and γ-aminobutyric acid, and mitigate stress responses through the modulation of the hypothalamic-pituitary-adrenal axis. Acupuncture has demonstrated efficacy in...Weiterlesen

Neue Erkenntnisse zur Akupunktur beim ischämischen Schlaganfall: Orchestrierung des Neuro-Endokrin-Immun-Netzwerks Abstract Ischemic stroke (IS) is a major public health challenge with high rates of mortality and disability. Its pathophysiology is complex and multifactorial. Although the pathogenesis of IS originates from local cerebral ischemia, it progresses to a systemic disorder involving dysfunction of the neuro-endocrine-immune (NEI) network. Acupuncture, a non-pharmaceutical therapy characterized by holistic regulation, holds considerable potential for correcting multi-system imbalances after IS. Nevertheless, how acupuncture coordinates this multi-system network remains poorly understood. This review synthesizes current evidence on the cellular and molecular mechanisms underlying acupuncture’s regulation of neural signaling,...Weiterlesen

Klinische Wirkung und Einflussfaktoren der Akupunktur bei motorischen Funktionsstörungen der Extremitäten nach ischämischem Schlaganfall: Eine systematische Übersicht und explorative Netzwerk-Metaanalyse Abstract Objective This study aimed to evaluate the clinical efficacy of acupuncture in the treatment of limb motor dysfunction following ischemic stroke, and to assess the influence of acupuncture intervention type and treatment dosage on therapeutic outcomes. Methods We conducted comprehensive searches multiple databases (e.g., PubMed, Embase, Cochrane, CNKI) and clinical trial registries for studies published up to 10 December 2024. Limb motor function, assessed using the Fugl-Meyer Assessment, was evaluated as the primary outcome. Data analysis was performed using...Weiterlesen

Akupunktur bei Migräne ohne Aura und konnektivitätsbasierte Wirksamkeitsvorhersage: Eine randomisierte klinische Studie Abstract Importance Connectome-based predictive modeling (CPM) uses a data-driven whole-brain framework to identify connectivity patterns predicting clinical outcomes. However, CPM’s application to acupuncture in migraine without aura (MWOA) remains novel. Objective To evaluate the clinical efficacy of real acupuncture and sham acupuncture in MWOA, and to identify acupuncture-response brain connectivity patterns using CPM analysis of baseline functional magnetic resonance imaging (fMRI) data. Design, setting and participants This single-blinded randomized clinical trial was conducted from June 2021 to June 2023 at Beijing Hospital of Traditional Chinese Medicine in China....Weiterlesen

Untersuchung der zentralen Nervenbahnen, die das Gehirn und periphere Akupunkturpunkte verbinden, unter Verwendung von Nervenmarkern Abstract Background Acupuncture is widely used for therapeutic purposes, but the neural mechanisms underlying its effects are not fully understood. This study aims to investigate the neural projections from acupoints and subcutaneous (sham acupoints) sites to the central nervous system, using retrograde tracing technology, to clarify the specificity of acupuncture’s neural pathways. Methods Adult C57BL/6J mice were injected with the retrograde tracer PRV-CAG-3 × mScarlet at seven acupoints (LI4, GV20, LI11, BL23, LR3, ST25, ST36) and their corresponding subcutaneous sites (sham acupoints). After 120 h, the brains were...Weiterlesen

Neuronale Korrelate der Akupunktur bei vaskulärer kognitiver Beeinträchtigung: Erkenntnisse aus der Ruhezustands-fMRT Abstract Vascular cognitive impairment (VCI) represents a spectrum of cognitive deficits caused by cerebrovascular pathology, affecting multiple cognitive domains including memory, executive function, and attention. While pharmacological interventions for VCI remain limited, growing evidence supports acupuncture as an effective and safe therapeutic approach that improves both global cognition and activities of daily living in affected patients. Nevertheless, the neurobiological mechanisms underlying acupuncture’s therapeutic effects require further elucidation. Resting-state functional magnetic resonance imaging (rs-fMRI) has emerged as a powerful neuroimaging tool for investigating brain function in cognitive disorders. This...Weiterlesen

Potenzielle Ziele der Kopfhautakupunktur und Hirnstimulation bei häufigen neurologischen Erkrankungen: Erkenntnisse aus Studien zur Neurobildgebung Abstract Background Scalp acupuncture is a promising potential therapy for neurological disorders. However, the development of its stimulation targets—both in identifying novel targets and refining the precision of their localization—has advanced slowly, largely due to the inadequate integration of brain science findings. This study leverages advances in brain neuroimaging to identify evidence-based cortical targets, enhancing the potential of scalp acupuncture and other brain stimulation techniques. Methods Using the Neurosynth Compose platform, systematic meta-analyses of neuroimaging studies were conducted to identify potential surface cortical targets for...Weiterlesen

Modulation der Gehirnaktivitäten bei gesunden Individuen durch Akupunktur am Dickdarm 11 Abstract This study investigated the effect of acupuncture at Quchi (LI11) on brain activities in healthy individuals. Sub-band power and EEG microstate analyses were conducted during pre-acupuncture, acupuncture, needle-retention, and post-acupuncture phases in both the acupuncture group (n = 16) and the control group (n = 18). Four microstate classes (A–D) were identified. Regression analyses and two-factor ANOVAs with Bonferroni correction were performed. The acupuncture group exhibited a significant reduction in beta power during the acupuncture phase. Further analysis revealed that acupuncture at LI11 mainly affected delta, theta, and...Weiterlesen