Pharmakologische Einblicke in die Traditionelle Chinesische Medizin bei Herzinsuffizienz: Fokus auf kardialen Energiestoffwechsel und Mitochondrienfunktion Abstract Introduction Heart failure (HF) remains a major contributor to global cardiovascular mortality, largely due to disturbances in myocardial energy balance and mitochondrial impairment. Conventional therapies alleviate symptoms and slow disease progression but seldom restore normal cardiac bioenergetics. Traditional Chinese Medicine (TCM) provides a holistic, multitarget therapeutic framework that can influence metabolic and signaling networks involved in maintaining cardiac energy homeostasis. Methods Following the PRISMA framework, a systematic search was carried out for publications from 2021 to 2025 examining TCM-derived compounds or formulations with regulatory...Weiterlesen

Auswirkung der Spezifität von Akupunkturpunkten auf kardiovaskuläre Outcomes: Eine systematische Überprüfung und Meta-Analyse Abstract Background Acupuncture, a cornerstone of Traditional Chinese Medicine (TCM), is increasingly utilized for cardiovascular diseases (CVDs). A central tenet is acupoint specificity – the hypothesis that stimulating specific acupoints yields distinct therapeutic effects compared to non-specific points or sham interventions. However, the empirical evidence supporting acupoint specificity for cardiovascular outcomes remains debated. This systematic review aimed to evaluate the current evidence regarding the impact of acupoint specificity on clinically relevant cardiovascular outcomes. Methods A systematic search was conducted in major biomedical databases (PubMed, Embase, Cochrane Library,...Weiterlesen

Auswirkungen der Akupunktur auf die Sterblichkeit bei Patienten mit Behinderungen und neu diagnostizierter Herzinsuffizienz: eine landesweite Kohortenstudie Abstract Objective People with disabilities have high rates of cardiovascular diseases and mortality, and heart failure can worsen their condition. Therefore, preventing and managing cardiovascular diseases is particularly important for this population. Although acupuncture has been used for heart failure, research on its impact on mortality is limited. Given the unique pathophysiological characteristics of people with disabilities, this study aimed to evaluate the effect of acupuncture on mortality in those newly diagnosed with heart failure. Methods This retrospective cohort study used data from...Weiterlesen

Akupunktur-Dosierung und ihre Korrelation mit der Wirksamkeit bei Patienten mit chronischer stabiler Angina pectoris: Eine systematische Übersicht und Meta-Analyse randomisierter kontrollierter Studien Abstract Objective This systematic review aimed to compare the efficacy of various acupuncture dosages for Chronic Stable Angina (CSA) using randomized controlled trials (RCTs), addressing the unclear relationship between dosage and effectiveness despite acupuncture’s potential. Methods We searched eight bibliographic databases from inception to October 31, 2024, evaluating RCTs comparing acupuncture to placebo or standard care for CSA patients, focusing on angina attack frequency as the primary outcome. Studies were categorized into high (HDG), moderate (MDG), and low...Weiterlesen

Abstract Background and ObjectivesIn this study, we attempted to determine the effects of acupuncture on cardiac remodeling and atrial fibrillation (AF) recurrence rates in patients with AF after electrical cardioversion (EC). Materials and MethodsWe randomly assigned 44 patients with persistent AF to an acupuncture group or a sham acupuncture group. An electroacupuncture treatment session was administered once weekly for 12 weeks at four acupuncture points (left PC5, PC6, ST36, and ST37). ResultsAmong the 44 recruited participants, 16 (treatment group) and 15 (control group) completed the trial. The three-month AF recurrence rate (primary outcome) was not significantly different between the two...Weiterlesen

Abstract ETHNOPHARMACOLOGICAL RELEVANCEFufang Chuanxiong capsule consists of Angelica sinensis radix and Chuanxiong rhizome, which are used in the traditional Chinese medicine for the treatment of coronary artery disease, and Xinyue capsule is composed of panax quinquefolius saponin extracted from leaves and stems of Panax quinquefolium L, which has the functions of anti-myocardial ischemia, improving myocardial energy metabolism and inhibiting apoptosis of cardiomyocytes. OBJECTIVETo observe the role of Chinese herbal medicines in the cardiovascular outcome among patients with acute coronary syndrome (ACS) and renal insufficiency after percutaneous coronary intervention (PCI). METHODSThe subjects came from the 5C trial (chictr.org number: chictr-trc-07000021), post-PCI...Weiterlesen

Abstract ETHNOPHARMACOLOGICAL RELEVANCEWith the extensive recent use of warfarin and traditional Chinese medicine (TCM) in combination, TCM has been found to affect warfarin’s pharmacokinetic and pharmacodynamic parameters. Warfarin is a widely used oral anticoagulant, which has a narrow therapeutic window and a high likelihood of interacting with other drugs and resulting in serious adverse reactions. Contrary to widespread public expectations, TCM, despite being natural, is not always safe. AIM OF THE STUDYTo report the adverse drug reactions (ADR) resulting from the use of Chinese medicine and warfarin sodium tablets in combination. METHODSAccording to a hospital ADR monitoring report, we collected...Weiterlesen

Abstract The use of traditional Chinese medicine (TCM) has obtained more and more acceptance all over the world due to its multi-target and multi-level function characteristics. Clopidogrel is a major therapeutic option to reduce atherothrombotic events in patients with acute coronary syndrome, recent myocardial infarction, recent stroke or established peripheral arterial disease. These patients probably take TCM. Are there any interactions between clopidogrel and TCM? Whether TCM will affect the efficacy of clopidogrel or increase the adverse reactions of bleeding? Clarifying this information will help physicians make better use of TCM. A literature search was carried out using Web of...Weiterlesen

Abstract The increased resting heart rate (HR) in heart transplant patients is associated with enhanced metabolic demand, the potential for fatigue, and lower quality of life. In the present study, we hypothesized that transcutaneous electrical acupoint stimulation (TEAS) could modulate autonomic balance and reduce resting HR in these patients. A single-arm clinical trial was conducted with patients aged > 18 years, at ambulatorial accompaniment after heart transplantation, who were submitted to a single TEAS (40 minutes at pericardium channel acupoints PC5 and PC6). The arterial blood pressure and RR interval were recorded from 20 minutes before to 20 minutes after...Weiterlesen

Abstract Importance The effects of acupuncture as adjunctive treatment to antianginal therapies for patients with chronic stable angina are uncertain. Objective To investigate the efficacy and safety of acupuncture as adjunctive therapy to antianginal therapies in reducing frequency of angina attacks in patients with chronic stable angina. Design, Setting, and Participants In this 20-week randomized clinical trial conducted in outpatient and inpatient settings at 5 clinical centers in China from October 10, 2012, to September 19, 2015, 404 participants were randomly assigned to receive acupuncture on the acupoints on the disease-affected meridian (DAM), receive acupuncture on the acupoints on the...Weiterlesen