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2 Studies on the treatment of male immune infertility with Chinese herbal formulas

The TCM treatment of male immune-related infertility

The authors report excellent results in their treatment of male immune-related infertility. Two hundred cases of male infertiity were randomly divided into two equal groups, one of which received prednisone (control) and the other Chinese herbs (treatment). In both groups the duration of the disease was from two to six years and the average age was 28.75 years. The men had various combinations of abnormal sperm density and motility, seminal and serum antisperm antibodies, chronic prostatitis, epididymitis and seminal mycoplasma. The Chinese herbal formula given to the treatment group was Yikang Tang which soothes the Liver, reinforces the Kidney, clears toxic heat and dampness, invigorates the blood and dispels blood stasis. It consists of Chai Hu (Bupleuri Radix) 9g, Sheng Di Huang (Rehmanniae Radix) 10g, Chuan Xiong (Chuan Xiong Rhizoma) 9g, Bai Hua She She Cao (Hedyotis Diffusae Herba) 12g, Ban Zhi Lian (Scutellariae Barbatae Herba) 10g, Bai Dou Kou (Amomi Rotundus Fructus) 9g, Yin Yang Huo (Epimedii Herba) 12g, Sheng Huang Qi (Astragali Radix) 20g, Mu Dan Pi (Moutan Cortex) 9g, Zhi Mu (Anemarrhenae Rhizoma) 9g and Huang Bai (Phellondri Cortex) 9g. Results showed that sperm density and motility increased significantly in the treatment group compared to the control, and that antisperm antibodies and sperm agglutination decreased significantly. The treatment group thus showed a significant improvement in fertility compared to the control, and this was further confirmed by the pregnancy rates in the treatment group which were double those of the control. In addition, 82% of patients in the treatment group maintained the gains they had made when assessed three months after the end of the trial, compared to approximately half of that figure in the control. The authors conclude that not only were the Chinese herbs more effective than the Western medicine but they were also free of the side-effects of prednisone in long-term use and its rebound effect.

The TCM treatment of male immune-related infertility by Sun Zhongming et al.
JTCM March 2006
Quelle: www.jcm.co.uk

 

Clinical Study on Treatment of Male Immune Infertility with Sheng Jing Zhong Zi Tang

The authors report on the treatment of 90 cases of male infertility using Sheng Jing Zhong Zi Tang (Decoction for Promoting Generation of Vital Energy). All of the 90 cases were married men who had been living with their spouses for at least two years (Infertility factors from the females were ruled out). Patients were given a Sperm Immobilisation Test (SIT) and Gelatine Agglutination Test (GAT), and IgA, LgG and IgM were measured. The patients were randomly divided into a control group and a treatment group. Among the 30 cases in the control group, there were 7 cases with positive SIT, 9 with positive GAT and 14 with positive SIT and GAT. And of the 60 cases in the treatment group, there were 11 cases with positive SIT, 23 with positive GAT and 26 with positive SIT and GAT. Statistically, there were no obvious differences between the two groups (P>0.05). Sheng Jing Zhong Zi Tang was prescribed to the treatment group, which consisted of Prepared Shu Di Huang (Radix Rehmanniae Preparata) 15g, Shan Zhu Yu (Fructus Corni) 6g, Zi He Che (Placenta Hominis) 10g, Bai Zhu (Rhizoma Atractylodis Macrocephaiae) 9g, Xu Duan (Radix Dipsaci) 9g, Xi Yang Shen ( Radix Panacis Quinquefolii) 6g, Hong Hua (Flos Carthami) 2g, Xian Mao (Rhizoma Curculiginis) 12g, Lu Rong (Cornu Cervi Pantotrichum) 3g, Tu Si Zi (Semen Cuscutae) 15g, Yin Yang Huo (Herba Epimedii) 12g, Gou Qi Zi (Fructus Lycii) 12g, Fu Pen Zi (Fructus Rubi) 12g, Wu Wei Zi (Fructus Schisandrae)15g and Sang Shen (Fructus Mori) 12g. The decoction was taken one dose a day, and the patients were allowed to have a normal sexual life. For the control group, prednisone (5mg) and clomiphene (1 tablet) were prescribed once daily. This group was encouraged to use condoms. One therapeutic course consisted of 60 days for both groups. SIT and GAT were measured after each therapeutic course. For those with negative finding drugs were withdrawn, but for those with positive findings, the above-mentioned drugs were provided continuously for another therapeutic course. IgA, IgG and IgM were also tested after completion of each therapeutic course so as to observe the changes. Of the 30 cases in the control group, 4 cases were cured (pregnancy within one year of the first therapeutic course), 13 cases effective (pregnancy after completion of 2-3 courses of treatment), and 13 cases failed. The total effective rate was 56.6%. Of the 60 cases in the treatment group, 15 cases were cured, 35 cases effective, and 10 cases failed. The total effective was 80.0%. Reductions in immunoglobulin indices (IgA, IgG, IgM) were significantly lower in both groups but more so in the treatment group taking Sheng Jing Zhong Zi Tang.

JTCM June 2002 Quelle: www.jcm.co.uk

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