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Studien zum Thema Onkologie

Compound Zhebei granules combined with chemotherapy for the treatment of refractory acute leukemia: a randomized clinical trial

Abstract OBJECTIVE To observe the effect of compound Zhebei granules (CZBG) with chemotherapy in the treatment of refractory acute leukemia. METHODS In this multicenter, double-blind, placebo-controlled clinical trial, we used a central (online) randomization system to assign 235 patients to two treatment groups. A total of 118 patients received chemotherapy combined with CZBG (4 g, twice daily) and 117 patients received chemotherapy plus placebo. The clinical efficacy was evaluated at the end of one chemotherapeutic cycle. RESULTS In the full analysis set, in which deaths due to disease progression were regarded as inefficacy, the rates of complete remission (CR) and partial remission (CR+PR) were 32.35%...
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Ren Shen Yang Rong Tang reduces cancer survivors’ fatigue

In a collaborative study between Chinese and US cancer centres, the Chinese formula Ren Shen Yang Rong Tang (RSYRT, ‘Ginseng Decoction to Nourish the Nutritive Qi’) has been found to significantly reduce severe fatigue in cancer patients. RSYRT is a tonic formula containing 12 herbs: Bai Shao (Radix Paeoniae alba, Dang Gui Radix (Angelicae Sinensis) Chen Pi (Pericarpium Citri Reticulatae), Huang Qi (Radix Astragali), Rou Gui (Cortex Cinnamomi Cassiae), Ren Shen (Radix Ginseng), Bai Zhu (Rhizoma Atractylodis Macrocephalae, Gan Cao (Radix Glycyrrhizae), Shu Di Huang (Radix Rehmanniae Glutinosae Praeparata, Wu Wei Zi (Fructus Schisandrae Chinensis), Fu Ling (Sclerotium Poriae Cocos),...
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Ohr-Akupressur gegen Chemotherapie-induzierte Obstipation

Verstopfung als Nebenwirkung einer Chemotherapie bei Brustkrebspatientinnen kann durch Ohr-Akupressur gelöst werden, so das Ergebnis einer randomisierten klinischen Studie aus Korea. Die Diagnose Brustkrebs ist der Beginn eines langwierigen therapeutischen Prozesses, zumeist einhergehend mit einer chemotherapeutischen Behandlung der Patientin, welche die Überlebenschancen der betroffenen Frauen erhöht, jedoch mit etlichen Nebenwirkungen verbunden ist. Dazu gehören Appetitmangel, Übelkeit und Erbrechen, wodurch die Patientinnen weniger Nahrung aufnehmen, weniger körperlich aktiv sind und unter Verdauungsstörungen in Form von Verstopfung leiden. Diese können durch die Einnahme von Antiemetika, Antidepressiva und Schmerzmitteln noch verstärkt werden. Eine zusätzliche medikamentöse Behandlung der Obstipation ist aufgrund der bereits vorhandenen...
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Kann Prostatakrebs durch pflanzliche Arzneimittel gebremst werden?

Die Behandlung von Prostatakrebs erfolgt üblicherweise mittels Bestrahlung, Hormonentzugstherapie oder Operation. Ein im Blut nachweisbares Tumormerkmal zur Beobachtung des Krankheitsverlaufs bei Prostatakrebs ist das sogenannte Prostata-Spezifische Antigen (PSA). Kommt es nach einer zunächst erfolgreichen Behandlung dennoch zum Anstieg dieses Tumormerkmals im Blut, spricht man von einem biochemischen Krankheitsrückfall, d. h. der Prostatakrebs schreitet fort. Häufig verwenden die betroffenen Männer dann pflanzliche Arzneimittel, wie z. B. Kräuterpräparate, um die Bildung von Tumorabsiedlungen (Metastasen) im Körper zu verzögern und weitere aggressive Therapien mit unerwünschten Nebenwirkungen, wie z. B. die körperlich sehr belastende Chemotherapie, erstmal zu vermeiden. Somit sind die pflanzlichen Arzneimittel, sogenannte...
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Electro-stimulation improves immunity in post-op lung cancer

Transcutaneous acupoint electrical stimulation (TAES) may improve postoperative immune depression in patients with lung cancer, by regulating the balance of T cells and their related cytokines. In a Chinese pilot study, 90 patients with lung cancer underwent TAES (frequency, 2/100 Hz; intensity, 4-12 mA) at bilateral Hegu L.I.-4, Neiguan P-6, Houxi SI-3 and Zhigou SJ-6 for 30 minutes prior to surgical incision, and at 20, 44, 68, 92 and 116 hours following thoracotomy. Following thoracotomy without TAES, down-regulated expression levels of Th1/Th17-associated cytokines and transcription factors, and up-regulated expression levels of Th2-associated cytokines and transcription factors were observed, indicative of...
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Electrical acupuncture stimulation helpful in palliative lung cancer care

Transcutaneous electrical acupuncture stimulation (TEAS) can reduce anxiety, promote rehabilitation and increase quality of life (QoL) in lung cancer patients receiving palliative care. A total of 188 participants were enrolled by Chinese investigators into three groups; a TEAS group, who received palliative care plus electrical stimulation at Zusanli ST-36, Sanyinjiao SP-6 and Hegu L.I.-4, a sham group who received palliative care plus electrical stimulation at non-acupoints, and a control group who received palliative care alone, for a seven day period. Anxiety scores decreased significantly in the TEAS group after treatment, while there were no significant improvement in the sham group....
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Effectiveness of Curcumin for Treating Cancer During Chemotherapy

ABSTRACT Oncologists tend to avoid the use of supplements during chemotherapy. To understand the safety issue, a literature review was conducted to evaluate safety and possible benefits of taking curcumin during chemotherapy. Curcumin was chosen because of its wide use in the public and because of the availability of clinical trials utilizing curcumin during chemotherapy. Curcumin is considered a “pan-assay interference compound,” creating false leads in drug discovery assays. The pharmacodynamics of curcumin presents many challenges for a therapeutic agent, including poor bioavailability and rapid metabolism and excretion. The proposed molecular targets for curcumin include inhibition of nuclear factor kappa...
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Acupuncture Alleviates Chemoradiotherapy Induced Leukopenia

Researchers find acupuncture combined with moxibustion effective for the treatment of chemoradiotherapy induced leukopenia. Shanghai Tongji Hospital researchers determined that acupuncture combined with moxibustion successfully increases white blood cell levels and stabilizes the overall health of patients suffering from leukopenia (a disorder characterized by reduced white blood cell levels). The results were verified by blood assays and additional clinical evidence in a controlled trial comparing the effects of medications with acupuncture and moxibustion. Acupuncture combined with moxibustion produced a positive patient outcome rate of 90.0%. The medications batilol and leucogen produced a 53.3% positive patient outcome rate for the treatment...
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Die Behandlung von Hitzewallungen bei Brustkrebs-Patientinnen mit Akupunktur

Alternative Medizin bei Krebspatienten Brustkrebs-Patientinnen können unter Hitzewallungen leiden, wenn sie mit Hormonen behandelt werden. Zur Behandlung dieser Wärmeschübe gerät die Akupunktur in den Blickpunkt, jedoch sind die wissenschaftlichen Ergebnisse zur Wirksamkeit nicht eindeutig. Brustkrebs ist die häufigste Krebserkrankung bei Frauen. Nach aktuellen Zahlen des Robert-Koch-Instituts [1] bekommen 29 von 100 Frauen, die neu an Krebs erkranken, Brustkrebs. Die Behandlung erfolgt meist durch die Entnahme des kranken Gewebes in einer Operation. Anschließend folgen oft Bestrahlung und Chemotherapie. Ziel ist die vollständige Entfernung des infizierten Gewebes, der Erhalt der Brust und schließlich die Heilung. Um einem Wiederauftreten des Krebses vorzubeugen, nehmen...
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Curcumin – Gegen Krebs ist eine Wurzel gewachsen

ABSTRACT Curcumin Trotz des medizinischen Fortschritts stirbt in Deutschland jeder Vierte an Krebs. Fieberhaft wird daher nach wirksamen Mittel gegen diese „Pest“ unserer Zeit gesucht. Die Natur hält die Antwort zur Lösung des Krebsproblems bereit. Es ist schlüssig bewiesen, dass bestimmte pflanzliche Stoffe, die natürlich in der Nahrung vorkommen, die Fähigkeit haben, Krebs zu verhindern. Einer dieser wichtigen Wirkstoffe unter diesen „bioaktiven Pflanzenstoffen“ ist Curcumin. Curcumin ist der aus der Gelbwurz (Kurkuma, Turmeric) gewonnene gelbe Farbstoff. Diese Heilpflanze wird vorwiegend in Afrika und Asien angebaut. Als Gewürz des Lebens ist Curcumin seit Jahrtausenden in der ayurvedischen Medizin bekannt. Conclusio: Bei...
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Comparative effectiveness of electro-acupuncture versus gabapentin for sleep disturbances in breast cancer survivors with hot flashes: a randomized trial

Objective: Sleep disturbance is a major consequence of hot flashes among breast cancer survivors. This study evaluated the effects of electro-acupuncture (EA) versus gabapentin (GP) for sleep disturbances among breast cancer survivors experiencing daily hot flashes. Methods: We analyzed data from a randomized controlled trial involving 58 breast cancer survivors experiencing bothersome hot flashes at least two times per day. Participants were randomly assigned to receive 8 weeks of EA or daily GP (total dose of 900 mg/d). The primary outcome was change in the total Pittsburgh Sleep Quality Index (PSQI) score between groups at week 8. Secondary outcomes include specific PSQI domains. Results: By the end of treatment at week 8, the mean reduction in...
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Chinesische Heilkräuter gegen Übelkeit und Erbrechen während der Chemotherapie

Übelkeit und Erbrechen als Folge einer chemischen Krebstherapie belasten die betroffenen Patienten oft zusätzlich. Wo konventionelle Antiemetika nicht helfen, können pflanzliche Zubereitungen aus der Traditionellen Chinesischen Medizin eine Alternative sein. Über 70 % der mit Oxaliplatin behandelten Krebspatienten leiden unter Übelkeit und Erbrechen. Oftmals nehmen diese Symptome mit der Häufigkeit der Behandlungszyklen zu und mindern die Lebensqualität nachhaltig. Die pharmakologischen Mechanismen, wie es im menschlichen Organismus zur Ausprägung der Magen-Darm-Beschwerden kommt, sind relativ komplex und erschweren somit eine erfolgreiche Behandlung. Konventionelle Antiemetika zeigen nicht bei allen Patienten die gewünschte Wirkung, so dass auch alternative Behandlungsmethoden im Fokus der Forschung stehen....
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Adjunctive Traditional Chinese Medicine Therapy Improves Survival in Patients With Advanced Breast Cancer

BACKGROUND: Traditional Chinese medicine (TCM) is one of the most common complementary and alternative medicines used in the treatment of patients with breast cancer. However, the clinical effect of TCM on survival, which is a major concern in these individuals, lacks evidence from large-scale clinical studies. METHODS: The authors used the Taiwan National Health Insurance Research Database to conduct a retrospective population-based cohort study of patients with advanced breast cancer between 2001 and 2010. The patients were separated into TCM users and nonusers, and Cox regression models were applied to determine the association between the use of TCM and patient...
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Acupuncture Versus Venlafaxine for the Management of Vasomotor Symptoms in Patients With Hormone Receptor– Positive Breast Cancer: A Randomized Controlled Trial

Vasomotor symptoms are common adverse effects of antiestrogen hormone treatment in conventional breast cancer care. Hormone replacement therapy is contraindicated in patients with breast cancer. Venlafaxine (Effexor), the therapy of choice for these symptoms, has numerous adverse effects. Recent studies suggest acupuncture may be effective in reducing vasomotor symptoms in menopausal women. This randomized controlled trial tested whether acupuncture reduces vasomotor symptoms and produces fewer adverse effects than venlafaxine. Patients and Methods Fifty patients were randomly assigned to receive 12 weeks of acupuncture (n  25) or venlafaxine (n  25) treatment. Health outcomes were measured for up to 1 year post-treatment....
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Acupuncture significantly reduces joint pain for breast cancer patients

In the largest, most rigorous study of its kind, acupuncture was found to significantly reduce the debilitating joint pain experienced by tens of thousands of women each year while being treated for early stage breast cancer, according to SWOG research results to be announced at a December 7 press conference at the San Antonio Breast Cancer Symposium. Investigators from SWOG, the global cancer clinical trials network funded by the National Cancer Institute (NCI), conducted a randomized, blinded, multicenter trial, known as S1200, to test whether acupuncture is effective in alleviating pain caused by aromatase inhibitors, a common treatment for hormone...
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Acupuncture reduces cancer pain

A pilot study carried out in China suggests that acupuncture may be effective for reducing cancer pain. In a randomised trial, 42 patients with moderate to severe cancer pain were randomly assigned to three different groups. Those in group one were needled at the ‘Four Gates’ (Si Guan  – bilateral Hegu L.I.4 and Taichong LIV-3), group two received needling at the Four Gates combined with bilateral Neiguan P-6, Zusanli ST-36 and Sanyinjiao SP-6, and group three received needling at bilateral Neiguan P-6, Zusanli ST-36 and Sanyinjiao SP-6 only. All received seven sessions of treatment over a two-week period. Patients in...
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ACUPUNCTURE PROTECTS WHITE BLOOD CELLS DURING CHEMOTHERAPY

An American pilot study suggests that acupuncture may have a protective effect on white blood cell (WBC) populations in women undergoing chemotherapy for gynaecological malignancies. Twenty-one ovarian cancer patients received either active or sham acupuncture while undergoing myelosuppressive chemotherapy. A standardised acupuncture protocol involving manual and electrical stimulation was applied two to three times per week for a total of 10 sessions, starting one week before the second cycle of chemotherapy. The median leukocyte value in the acupuncture group was significantly higher on the first day of the third cycle of chemotherapy than in the control (8600 cell/µL versus 4400...
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Acupuncture Prevents Chemotherapy Nausea and Vomiting

Quelle: http://www.healthcmi.com  Acupuncture is effective for the prevention of nausea and vomiting caused by cisplatin based chemotherapy. Researchers at the Cangzhou Hospital of Integrated Traditional and Western Medicine (Hebei, China) conducted a study comparing the effects of drug therapy as a standalone procedure with acupuncture combined with drug therapy. Based on the data, the researchers conclude that acupuncture plus antiemetic drug therapy is significantly more effective than using only antiemetic drug therapy. Two groups were compared. In one group, chemotherapy patients received only tropisetron hydrochloride as a means to control nausea and vomiting. In the second group, tropisetron hydrochloride was...
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Acupuncture Plus Herbs Relieve Chemo Neurotoxicity

Quelle (15 APRIL 2016): http://www.healthcmi.com Acupuncture and herbs produce optimal positive patient outcomes for patients with peripheral neuropathy due to chemotherapy. Research demonstrates that acupuncture and herbs alleviate pain and numbness of the arms and legs caused by the adverse effects of chemotherapy for patients with several types of cancer. The results demonstrate that a combined protocol of acupuncture and herbal medicine produces a 90% total effective rate for the relief of pain and numbness. LI4 (Hegu) Needling Acupuncture and Chinese herbal medicine alleviate extremity pain and numbness induced by chemotherapy neurotoxicity according to research published in the Shandong Medical...
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Acupuncture Lowers Chemo Side Effects, Ups Immunity

Quelle (11 JUNE 2014): http://www.healthcmi.com Acupuncture reduces chemotherapy side effects for colorectal cancer patients. New research confirms that acupuncture benefits the immune system and improves the psychological state for these patients. Blood samples prove that acupuncture enhances the immune system’s NK (natural killer) cells for colorectal cancer patients. Subjective testing showed improved mental health scores after acupuncture. The researchers concluded that acupuncture is both “feasible and safe for CRC (colorectal cancer) patients….” The research team commented that NK cells are “a first line of defence against the metastatic spread of tumour cells.” Data shows that decreases in NK cell numbers and...
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Acupuncture improves immunity in chemo patients

Acupuncture and moxibustion may stimulate anti-cancer immunity, protect bone marrow cells and minimise drug side-effects in colon cancer patients undergoing chemotherapy, according to a pilot study carried out in Portugal. Eighteen cancer patients were randomised to either acupuncture treatment or a wait list control group. Patients in the treatment group received six sessions of acupuncture twice a week, beginning one week prior to their first cycle of chemotherapy and ending at the beginning of the following cycle of chemotherapy. The experimental group received acupuncture at Taichong LIV-3, Zusanli ST-36, Sanyinjiao SP-3, and Xuanzhong GB-39, Hegu L.I.-4, Jianshi PC5, Waiguan SJ-5...
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Acupuncture helps with dry mouth

Twelve patients with radiation-induced xerostomia were randomised into real or sham acupuncture groups. Acupuncture was conducted twice weekly for six weeks in a single-blind setting. The effect was evaluated by measuring salivary flow rates (stimulated and unstimulated) and questionnaire-based assessment of subjective symptoms pre- and at three and six weeks post-treatment. Both groups showed a slight increase in salivary flow rates, with no significant difference between them. However, real acupuncture markedly increased unstimulated salivary flow rates, and improved the score for dry mouth according to a xerostomia questionnaire, by 2.33 points versus 0.33 in controls. The authors conclude that the...
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Acupuncture helps with cancer fatigue

Acupuncture may be a useful adjunctive treatment for reducing fatigue in palliative cancer care, report Chinese investigators. They performed a randomised pilot trial on 28 lung cancer patients presenting with cancer-related fatigue (CRF) who were randomly assigned to receive verum acupuncture (bilateral Hegu L.I.-4, Qihai REN-6, Zusanli ST-36, Taichong KID-3 and Sanyinjiao SP-6) or placebo acupuncture (using a non-penetrating placebo needle at the same points), twice per week for four weeks. A significant reduction in fatigue scores was observed after two weeks of treatment in the participants who received verum acupuncture compared with those receiving the placebo treatment. At week...
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Acupuncture Helps Lung Cancer Patients

Quelle (10 JUNE 2013): http://www.healthcmi.com A groundbreaking new study concludes that acupuncture treatments correlate to improvements in symptoms experienced by lung cancer patients. The study notes that lung cancer patients experience pain, depression, anxiety, nausea and a lack of well-being associated with either the disease or cancer treatments. The researchers discovered that a minimum of six acupuncture treatments was required to exert a 70% chance of a “clinically important improvement in well-being.” The study demonstrated that acupuncture treatments improved symptoms including pain, appetite loss, nausea, anxiety and an overall feeling of well-being. The researchers note that there is a clinically...
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Acupuncture for Treating Aromatase Inhibitor–Related Arthralgia in Breast Cancer: A Systematic Review and Meta-Analysis

ABSTRACT Purpose: Acupuncture has been used as a complementary medical treatment for arthralgia and other types of pain. The objective of this review is to assess the effectiveness of acupuncture in the treatment of arthralgia in patients with breast cancer who were treated with aromatase inhibitors (AIs). Methods: A literature search was performed, without language restrictions, of 10 databases from their inception through February 2014. The literature reviewed included randomized clinical trials (RCTs) and clinical trials that compared real versus sham acupuncture for the treatment of AI-related musculoskeletal symptoms (AIMSS). The methodologic quality of these trials was assessed by using...
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Acupuncture effective integrative treatment for breast cancer hot flushes

Acupuncture in association with enhanced self-care is an effective integrative intervention for managing hot flushes and improving quality of life in women with breast cancer, according to Italian researchers. A pragmatic, randomised controlled trial compared acupuncture plus enhanced self-care versus enhanced self-care alone in 190 women with breast cancer. Both groups received a booklet with information about climacteric syndrome and its management, to be followed for at least 12 weeks. In addition, the acupuncture group received 10 l acupuncture treatment sessions. Evaluation of tongue and pulse was performed at each session and acupuncture was performed at three common acupoints (Sanyinjiao...
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Acupuncture as good as morphine for lung cancer breathlessness

A UK group has found acupuncture alone or in combination with morphine to be effective for the relief of breathlessness in lung cancer patients. The investigators randomised 173 patients with lung cancer and dyspnoea to an acupuncture group (A), a morphine group (M) or an acupuncture plus morphine group (AM). Acupuncture was administered at thoracic trigger points (upper sternal, paravertebral and trapezius) and Hegu L.I.-4. Semi-permanent manubrial acupuncture studs were also inserted and massaged when patients were symptomatic. All patients were allowed rescue morphine for breakthrough pain. Dyspnoea scores improved by more than 1.5 on a visual analogue scale in...
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Acupuncture Alleviates Chemotherapy Peripheral Neuropathy

Quelle (24 JULY 2015): http://www.healthcmi.com Researchers find acupuncture effective for alleviating chemotherapy induced peripheral neuropathy (CIPN) for patients with colon cancer. Neurotoxicity from chemotherapy may damage nerve fibers and lead to symptoms including pain, burning sensations, tingling, muscle weakness, balance disorders, paresthesia, dysesthesia, cold or heat sensitivity in the hands and feet, and a “glove and stocking” distribution of symptoms. The paresthesia is often experienced as a bilateral pins and needles sensation. Severity ranges from mild to debilitating. The researchers summarize their findings into three main benefits of acupuncture for patients with CIPN: Acupuncture administered prior to chemotherapy prevents CIPN. Use...
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