Auswirkungen akupunkturbezogener Therapien auf das Schwangerschaftsergebnis bei Frauen, die sich einer In-vitro-Fertilisation und einem Embryotransfer unterziehen: eine Bayes’sche Netzwerk-Meta-Analyse
Abstract
Background
This network meta-analysis aimed to assess the efficacy of different acupuncture-related therapies in improving pregnancy outcomes among women undergoing in vitro fertilization and embryo transfer (IVF-ET).
Methods
Randomized controlled trials (RCTs) examining acupuncture-related therapies as adjuncts to IVF-ET were systematically searched in eight databases from inception until January 15, 2025. Dichotomous outcomes concerning efficacy were evaluated as odds risk (OR) and continuous data as mean difference (MD) and 95% credible intervals (CrI) utilizing R 4.1.2 and Stata 16.1.
Results
Through a comprehensive literature search, we ultimately identified 96 RCTs that involved 14,736 participants and 15 interventions in this systematic analysis. Based on the clinical pregnancy rate outcome, warm acupuncture for three menstrual cycles before oocyte retrieval (WA-TTP, OR 3.56, 95% CrI 2.05 to 6.25, low certainty, SUCRA = 89.54%), acupuncture combined with moxibustion for three menstrual cycles before oocyte retrieval (AC + M-TTP, OR 3.31, 95% CrI 1.05 to 11.77, low certainty, SUCRA = 78.70%), and acupuncture for one menstrual cycle before oocyte retrieval (AC-OTP, OR 2.69, 95% CrI 1.76 to 4.09, moderate certainty, SUCRA = 77.98%) demonstrated potential superiority compared to false acupuncture or no treatment (F/N). Significant subgroup differences between clinical pregnancy rates were observed by subgroup analysis.
Conclusion
Acupuncture-related therapies can potentially enhance clinical pregnancy rates among women undergoing IVF-ET, with WA-TTP, AC + M-TTP, and AC-OTP demonstrating potential superiority. AC-TTP demonstrated a greater efficacy in improving live birth rates, increasing endometrial thickness, and reducing pulsation index. Our findings emphasize that acupuncture-related therapies with a limited number of sessions before or after embryo transfer show minimal clinical benefit except auricular acupressure.
Autoren
Chengli Bin, Hanzhi Zhong, Shipeng Zhang, Yiping Luo, Jiali Su, Maoya Li & Shaobin Wei
Journal
Journal of Assisted Reproduction and Genetics
Link: https://doi.org/10.1007/s10815-025-03489-3
Verwendete Punkte (Top 5):
- Ren Mai 4, 6
- Milz-Pankreas 6
- Magen 36
- Palast des Kindes
QUELLE:
Bin, C., Zhong, H., Zhang, S., Luo, Y., Su, J., Li, M., & Wei, S. (2025). Effects of acupuncture-related therapies on pregnancy outcomes among women undergoing in vitro fertilization and embryo transfer: a Bayesian network meta-analysis. Journal of Assisted Reproduction and Genetics, 1-14. https://doi.org/10.1007/s10815-025-03489-3