Akupunkturgestützte Lebensstilintervention verbessert den Stoffwechselstatus und die spontane Gehirnaktivität von Patienten mit Diabetes mellitus Typ 2: eine randomisierte klinische Studie
Abstract
Background
Aggressive weight management in patients with type 2 diabetes mellitus has demonstrated numerous metabolic advantages, however, existing therapies for weight control have not reached satisfactory results. This study aimed to evaluate the efficacy and safety of acupuncture in the weight management of type 2 diabetes mellitus (T2DM) patients by using a randomized, sham-controlled clinical trial design.
Methods
In this single-blind randomized clinical trial, 102 overweight adult T2DM patients were randomized into two groups. The control group receives diet, exercise, and sham acupuncture intervention, whereas the acupuncture group receives diet and exercise and acupuncture intervention, both for 1 month. Body weight and other anthropometric and laboratory indices were assessed at baseline and endpoint, meanwhile, the body fat content and spontaneous brain activity were measured by functional magnetic resonance imaging(fMRI)as the exploratory outcomes.
Results
No significant difference was observed between the studied parameters at the baseline. The body weight and BMI were significantly reduced both in the control and acupuncture groups after intervention, without statistical difference between the two groups. What’s interesting is that compared to the control, the acupuncture group displayed a greater improvement in central fat tissue. It notes that the acupuncture group achieved significant liver fat content reduction than the sham acupuncture group. At the same time, the spontaneous brain activity in the occipital lobe and parietal lobe significantly increased in the acupuncture group.
Conclusion
One month of acupuncture treatment preferentially improved ectopic fat deposition and was accompanied by changes in brain activity compared with the control group, even before significant changes in total body weight had occurred. further studies of longer duration are necessary for validation.
Autoren
Zhitian Zhang, Kaixuan Bao, Jiaojiao Liu, Chunfei Jiang, Chunyan Ji, Jiawei Han, Guo Zhou, Xiaoyu Liu, Tiemin Liu, Jian Gao, Xiangyu Wang & Hongmei Yan
Journal
Diabetology & Metabolic Syndrome
Link: https://link.springer.com/article/10.1186/s13098-024-01489-4
DOI: https://doi.org/10.1186/s13098-024-01489-4
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Verwendete Punkte: Magen 9 (ST9), Magen 10 (ST10), Magen 21 (ST21), Magen 25 (ST25),
Magen 29 (ST29), Magen 36 (ST36), Magen 40 (ST40), Magen 44 (ST44)