Auswirkung von Akupunktur auf die Proteomik der Tränen bei Patienten mit trockenem Auge aufgrund von Bildschirmgeräten
Abstract
Acupuncture is widely used to treat dry eye disease (DED),but its effect has not been reported in treating video display terminal(VDT)-related dry eye, and the mechanism of acupuncture on VDT-related dry eye is also unknown. In our study, the tear proteome wascompared with identifying possible mechanisms and biomarkers forpredicting acupuncture effectiveness in VDT-related dry eye. The resultsshowed that the ocular surface disease index scores were significantlydifferent between the acupuncture group (AC group) and artificial tearsgroup (AT group) at the end of the study, whereas tear film breakup time(TFBUT) and Schirmer I test (SIT) were not significantly differentbetween the groups. Proteome changes pre- and post-treatment in the ACgroup were associated with B cell-related immune processes, inflammation,glycolysis, and actin cytoskeleton. Furthermore, the proteins hexosamini-dase A and mannose-binding lectin 1 could prospectively predict whether acupuncture treatment was effective. Therefore, we believethat acupuncture can provide greater improvement in the clinical symptoms of VDT-related dry eye than artificial tears. Themechanism of acupuncture in VDT-related dry eye treatment may be associated with glycolysis- and actin cytoskeleton remodeling-mediated inflammatory and immune processes. Additionally, hexosaminidase A and mannose-binding lectin 1 are biomarkers forpredicting the efficacy of acupuncture for VDT-related dry eye.
Autoren
Na Tag, Lewei Tang, Jiacheng Lyu, Xiaohan Jiang, Yan Li, Chen Ding, Shenhjin Xiang
Journal
Journal of Proteome Research
DOI: https://doi.org/10.1021/acs.jproteome.4c00134
Kommentar:
Verwendete Punkte: Blase 2 (BL2), Außerhalb des Meridians (EX-HN5), Magen 2 (ST2),
Dickdarm 4 (LI4), San Jiao 23 (SJ23), Blase 1 (BL1), Gallenblase 20 (GB20), Du 20 (DU20)