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Studien Male infertility from JCM

1) Clinical Study On Treatment of Male Immune Infertility with Sheng Jing Zhong Zi Tang

JTCM June 2002 70/34
Yang Baocun et al
(Archive subscribers please click on ‘find out more’ to see abstract. The full article is not available online and must be bought as a photocopy delivered by post).
Clinical Study on Treatment of Male Immune Infertility with Sheng Jing Zhong
Zi Tang
Yang Baocun et al

The authors report on the treatment of 90 cases of male infertility using Sheng Jing Zhong Zi Tang (Decoction for Promoting Generation of Vital Energy). All of the 90 cases were married men who had been living with their spouses for at least two years (Infertility factors from the females were ruled out). Patients were given a Sperm Immobilisation Test (SIT) and Gelatine Agglutination Test (GAT), and IgA, LgG and IgM were measured. The patients were randomly divided into a control group and a treatment group. Among the 30 cases in the control group, there were 7 cases with positive SIT, 9 with positive GAT and 14 with positive SIT and GAT. And of the 60 cases in the treatment group, there were 11 cases with positive SIT, 23 with positive GAT and 26 with positive SIT and GAT. Statistically, there were no obvious differences between the two groups (P>0.05). Sheng Jing Zhong Zi Tang was prescribed to the treatment group, which consisted of Prepared Shu Di Huang (Radix Rehmanniae Preparata) 15g, Shan Zhu Yu (Fructus Corni) 6g, Zi He Che (Placenta Hominis) 10g, Bai Zhu (Rhizoma Atractylodis Macrocephaiae) 9g, Xu Duan (Radix Dipsaci) 9g, Xi Yang Shen ( Radix Panacis Quinquefolii) 6g, Hong Hua (Flos Carthami) 2g, Xian Mao (Rhizoma Curculiginis) 12g, Lu Rong (Cornu Cervi Pantotrichum) 3g, Tu Si Zi (Semen Cuscutae) 15g, Yin Yang Huo (Herba Epimedii) 12g, Gou Qi Zi (Fructus Lycii) 12g, Fu Pen Zi (Fructus Rubi) 12g, Wu Wei Zi (Fructus Schisandrae)15g and Sang Shen (Fructus Mori) 12g. The decoction was taken one dose a day, and the patients were allowed to have a normal sexual life. For the control group, prednisone (5mg) and clomiphene (1 tablet) were prescribed once daily. This group was encouraged to use condoms. One therapeutic course consisted of 60 days for both groups. SIT and GAT were measured after each therapeutic course. For those with negative finding drugs were withdrawn, but for those with positive findings, the above-mentioned drugs were provided continuously for another therapeutic course. IgA, IgG and IgM were also tested after completion of each therapeutic course so as to observe the changes. Of the 30 cases in the control group, 4 cases were cured (pregnancy within one year of the first therapeutic course), 13 cases effective (pregnancy after completion of 2-3 courses of treatment), and 13 cases failed. The total effective rate was 56.6%. Of the 60 cases in the treatment group, 15 cases were cured, 35 cases effective, and 10 cases failed. The total effective was 80.0%. Reductions in immunoglobulin indices (IgA, IgG, IgM) were significantly lower in both groups but more so in the treatment group taking Sheng Jing Zhong Zi Tang.

JTCM June 2002

 

2) TCM Treatment of Male Infertility Due to Seminal Abnormality

JTCM March 1990 34/33
Zhai Yachun et. al.
(Archive subscribers please click on ‘find out more’ to see abstract. The full article is not available online and must be bought as a photocopy delivered by post).
TCM Treatment of Male Infertility Due to Seminal Abnormality
by Zhai Yachun et.al.

82 male patients with infertility were treated with Ju Jing Powder, consisting of Shu Di Huang (Radix Rehmanniae Glutinosae Conquitae), Gou Qi Zi (Fructus Lycii Chinensis), He Shou Wu (Radix Polygoni Multiflori), Zi He Che (Placenta Hominis), Yin Yang Huo (Herba Epimedii), Sha Yuan Ji Li (Semen Astragali), Fu Ling (Sclerotium Poriae Cocos), Yu Zhu (Rhizoma Polygonati Odorati) and Yi Yi Ren (Semen Coicis Lachryma-jobi) with additions. The total effective rate was 85.4% with increased sperm density, sperm count and sperm motility.

JTCM March 1990

 

3) Home »The Journal »JCM Article Archive »

The Therapeutic Effect of Sheng Jing Zhing Zu Tang in Treating Male Infertility
JTCM June 2001 67/46
Yang Baocun et al.
(Archive subscribers please click on ‘find out more’ to see abstract. The full article is not available online and must be bought as a photocopy delivered by post).
The Therapeutic Effect of Sheng Jing Zhing Zu Tang in Treating Male Infertility
Yang Baocun et al

In the treatment group, 87 men between the ages of 26 and 38 had been unsuccessful in fathering a child for more than 2 years. 28 cases were deemed to belong to the TCM patterns of Kidney yang deficiency, 32 were Kidney yin deficiency, and 27 cases were both Kidney yang and Kidney yin deficiency. For comparative purposes, a “fertility” group of 30 healthy men of similar age, whose spouses had conceived within the last 2 years, was used. The basic formula for male infertility due to deficiency of both Kidney yang and Kidney yin is: Shu Di Huang (Radix Rehmanniae Glutinosae Conquitae) 15g, Shan Zhu Yu (Fructus Corni Officinalis) 6g, Zi He Che (Placenta Hominis) 10g, Bai Zhu (Rhizoma Atractylodis Macrocephalae) 9g, Xu Duan (Radix Dipsaci) 9g, Xian Mao (Rhizoma Curculiginis Orchioidis) 12g, Yin Yang Huo (Herba Epimedii) 12g, Tu Si Zi (Semen Cuscutae) 15g, Gou Qi Zi (Fructus Lycii Chinensis) 12g, Fu Pen Zi (Fructus Rubi) 12g, Wu Wei Zi (Fructus Schisandrae Chinensis) 6g and Sang Shen (Fructus Mori Albae) 12g. If insufficiency of Kidney yang prevailed, Lu Rong (Cornu Cervi Parvum) 3g, Yang Qi Shi (Actinolitum) 6g and Rou Cong Rong (Herba Cistanches) were added. If insufficiency of Kidney yin prevailed, Dang Gui (Radix Angelicae Sinensis) 12g and Nu Zhen Zi (Fructus Ligustri Lucidi) 12g were added. The decoction was given once daily. The criteria for therapeutic effectiveness were as follows: i. Cured – the patients spouse became pregnant; ii. Markedly Effective – sperm motility was significantly improved, there was at least a two-fold increase in sperm count, and a significant improvement in the morphology and quality of seminal plasma, iii. Effective – one of the three criteria above achieved, and iv. Ineffective – no significant improvement after treatment. After 1-3 courses of treatment, 49 cases (56.3%) were cured, 20 were markedly effective, 14 effective and for 4 cases treatment was ineffective. The total effective rate was 95.4%. As might be expected, before treatment the cumulative scores for sperm count, motility etc. were significantly lower in the treatment group than in the “fertility” group. After treatment these scores improved significantly (P< 0.001) with similar improvements in plasma hormone levels FSH, LH, T and C (P<0.05)

JTCM June 2001
SKU: a558pdf-7039

 

4) Effect On Humoral Immunity

JTCM December 1995 51/32
Chen Xiaopeng et. al.
(Archive subscribers please click on ‘find out more’ to see abstract. The full article is not available online and must be bought as a photocopy delivered by post).
Guyin Decoction on the Treatment of Immuno-Sterility and its Effect on Humoral Immunity
Chen Xiaopeng et. al.

Immuno-sterility (anti-sperm antibodies) constitutes about 20% of cases of female infertility. 60 patients in the treated group were given Guyin Decoction made up as follows: Ren Shen (Radix Ginseng) 9g, Sheng Di Huang (Radix Rehmanniae Glutinosae) 15g, Shan Yao (Radix Dioscoreae Oppositae) 20g, Shan Zhu Yu (Fructus Corni Officinalis) 10g, Zhi Yuan Zhi (Radix Polygalae Tenuifoliae) 9g, Tu Si Zi (Semen Cuscutae) 15g, Wu Wei Zi (Fructus Schisandrae Chinensis) 15g, Gan Cao (Radix Glycyrrhizae Uralensis) 15g. 25 cases in the control group were treated with 5mg of prednisolone and 100mg Vit. E daily. One course of treatment consisted of 20 days, after which SIT (sperm inhibition test) was performed. If the test was negative, treatment was stopped, otherwise another course was given and so on. Of the 60 cases in the treatment group 51 (85%) had the SIT turn to negative (8 in 1 course of treatment, 37 in 2 courses and 6 in 3 courses). Of the 60, 19 cases (31.7%) became pregnant within 1 year of treatment. Of the 25 in the control group, 14 (56%) had the SIT turn to negative, with 6 pregnancies (24%).

JTCM December 1995

 

5) The TCM treatment of male immune-related infertility

The TCM treatment of male immune-related infertility by Sun Zhongming et al.

The authors report excellent results in their treatment of male immune-related infertility. Two hundred cases of male infertiity were randomly divided into two equal groups, one of which received prednisone (control) and the other Chinese herbs (treatment). In both groups the duration of the disease was from two to six years and the average age was 28.75 years. The men had various combinations of abnormal sperm density and motility, seminal and serum antisperm antibodies, chronic prostatitis, epididymitis and seminal mycoplasma. The Chinese herbal formula given to the treatment group was Yikang Tang which soothes the Liver, reinforces the Kidney, clears toxic heat and dampness, invigorates the blood and dispels blood stasis. It consists of Chai Hu (Bupleuri Radix) 9g, Sheng Di Huang (Rehmanniae Radix) 10g, Chuan Xiong (Chuan Xiong Rhizoma) 9g, Bai Hua She She Cao (Hedyotis Diffusae Herba) 12g, Ban Zhi Lian (Scutellariae Barbatae Herba) 10g, Bai Dou Kou (Amomi Rotundus Fructus) 9g, Yin Yang Huo (Epimedii Herba) 12g, Sheng Huang Qi (Astragali Radix) 20g, Mu Dan Pi (Moutan Cortex) 9g, Zhi Mu (Anemarrhenae Rhizoma) 9g and Huang Bai (Phellondri Cortex) 9g. Results showed that sperm density and motility increased significantly in the treatment group compared to the control, and that antisperm antibodies and sperm agglutination decreased significantly. The treatment group thus showed a significant improvement in fertility compared to the control, and this was further confirmed by the pregnancy rates in the treatment group which were double those of the control. In addition, 82% of patients in the treatment group maintained the gains they had made when assessed three months after the end of the trial, compared to approximately half of that figure in the control. The authors conclude that not only were the Chinese herbs more effective than the Western medicine but they were also free of the side-effects of prednisone in long-term use and its rebound effect.

JTCM March 2006

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