Die veränderte funktionelle Konnektivität des hypothalamischen Netzwerks bei chronischer Schlaflosigkeit und die regulierende Wirkung der Akupunktur: eine randomisierte kontrollierte bildgebende Studie
Abstract
Background
The hypothalamus has been recognized as a core structure in the sleep-wake cycle. However, whether the neuroplasticity of the hypothalamus is involved in the acupuncture treatment of insomnia remains elusive.
Methods
We recruited 42 patients with chronic insomnia disorder (CID) and 23 matched healthy controls (HCs), with CID patients randomly assigned to receive real acupuncture (RA) or sham acupuncture (SA) for four weeks. Insomnia severity was evaluated using the Pittsburgh Sleep Quality Index (PSQI) score, and the resting-state functional connectivity (rsFC) of the hypothalamus was assessed via functional magnetic resonance imaging (fMRI).
Results
In the cross-sectional investigation, CID patients showed increased rsFC between the medial hypothalamus (MH) and left lateral orbital frontal cortex (LOFC), and bilateral medial orbital frontal cortex (MOFC) compared to HCs. In the longitudinal experiment, PSQI scores significantly decreased in the RA group (p = 0.03) but not in the SA group. Interestingly, the increased MH-LOFC connectivity was found to be reduced following RA treatment. In addition, the altered rsFC of MH-LOFC significantly correlated with clinical improvement in the RA group (r = -0.692, p = 0.006).
Conclusion
This randomized neuroimaging study provides preliminary evidence that acupuncture may improve insomnia symptoms by restoring circuits associated with hypothalamic subregions.
Autoren
Wei Peng, Hao Xu, Chuanzhi Zhang, Youping Hu and Siyi Yu
Journal
BMC Complementary Medicine and Therapies
Link: https://bmccomplementmedtherapies.biomedcentral.com/articles/10.1186/s12906-024-04703-y
DOI: https://doi.org/10.1186/s12906-024-04703-y
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Verwendete Punkte: Du Mai 20 (DU20), Ren Mai 12 (RN12), Magen 36 (ST36)