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“5-Ling Granule” comparable to drug treatment for Tourette’s

The clinical efficacy of  ‘5-Ling Granule’ (5-LGr), a proprietary herbal formula, is comparable to that of the drug tiapride (a selective dopamine D2-receptor antagonist) for reducing tics in children with Tourette’s syndrome. In a multi-centre trial, Chinese investigators randomised 603 patients with TS to treatment with placebo, tiapride or 5-LGr for eight weeks. While all patients experienced a reduction in tics over time, 5-LGr and tiapride produced significantly greater improvements compared with placebo. 74% of patients in the 5-LGr arm and 68.3% in the tiapride arm showed a clinical response to treatment. These response rates were significantly higher than placebo (44%). The incidence of adverse events was significantly lower for patients on placebo and 5-LGr compared with tiapride (11.2% and 13.8% vs. 26.0%); in particular physical tiredness, dizziness and sleep disturbance.

A proprietary herbal medicine (5-Ling Granule) for Tourette syndrome: a randomized controlled trialJ Child Psychol Psychiatry.

2015 Jun 13. doi: 10.1111/jcpp.12432.


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