Kombinierte Pudendusnerv-Elektroakupunktur und transkranielle Akupunkturstimulation bei vorzeitiger Ejakulation: eine randomisierte klinische Studie
Abstract
Background
Premature ejaculation (PE) is a common and distressing condition with a multifactorial etiology and limited tolerable long-term treatment options. Current literature suggests that neuromodulatory approaches that simultaneously target peripheral reflex pathways and central regulatory mechanisms may provide additive therapeutic benefits.
Methods
In this single-center, block-randomized clinical study, 120 men with PE were assigned to an observation group (n = 60) or a control group (n = 60). The observation group received pudendal nerve electroacupuncture (PNEA) combined with repetitive transcranial acupuncture stimulation (rTAS) twice weekly for 8 weeks, whereas the control group received PNEA alone on the same schedule. Fifty-three participants in the observation group and 55 in the control group completed follow-up. Outcomes, including intravaginal ejaculation latency time (IELT), Premature Ejaculation Diagnostic Tool (PEDT), Self-rating Anxiety Scale (SAS), and Self-rating Depression Scale (SDS) scores, were assessed at baseline and at week 8.
Results
At week 8, the observation group exhibited a longer IELT and greater reductions in PEDT, SAS, and SDS scores than the control group (all p < 0.05). Overall response rates were 94.34% in the observation group and 83.64% in the control group (p = 0.12). No serious adverse events were observed, and reported adverse events were mild and transient.
Conclusions
Compared with PNEA alone, combined PNEA + rTAS provided greater improvements in ejaculatory latency and overall symptom burden over 8 weeks while maintaining good tolerability. These findings support integrated peripheral–central neuromodulation as a promising therapeutic option for PE and indicate that further confirmation in randomized, sham-controlled trials with longer follow-up is warranted.
Autoren: Jiawei Gong, Yinan Lyu, Houdong He, Hao Zhang, Tao Zhou, Yue Duan
Journal: Revista Internacional de Andrología
Link: https://doi.org/10.22514/j.androl.2026.013
DOI: 10.22514/j.androl.2026.013
Verwendete Punkte:
Transkranielle Akupunkturstimulation – Schädelbereich (rTAS):
- Kognitiv-affektives Areal: Frontaler Bereich entlang der anterior-posterioren Mittellinie, beidseitig erweitert auf Höhe des medialen Augenwinkels
Pudendusnerv-Elektroakupunktur (PNEA):
- 4 Punkte oberhalb der Symphysenmitte entlang der Pudendusnerv-Leitungsbahn, tief gestochen (100 mm Nadeln), mit Elektroakupunktur verbunden
QUELLE: Gong, J., Lyu, Y., He, H., Zhang, H., Zhou, T., & Duan, Y. (2026). Combined pudendal nerve electroacupuncture and transcranial acupuncture stimulation for premature ejaculation: a randomized clinical study. Revista Internacional de Andrología, 24(1), 105–114. https://doi.org/10.22514/j.androl.2026.013